What effect does Carprofen injection have on cattle?

Carprofen injection is used as an auxiliary agent of antibacterial drugs for the treatment of bovine infectious respiratory diseases and acute mastitis.

Clinical pharmacology of Carprofen injection

Carprofen injection is a non-narcotic, non-steroidal anti-inflammatory drug with analgesic and antipyretic activity comparable to indomethacin in animal models. Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class. Like other non-steroidal anti-inflammatory drugs, the mechanism of action of carprofen is thought to be related to the inhibition of cyclooxygenase activity. A number of studies have shown that Carprofen has a regulatory effect on both humoral and cellular immune responses.

Contraindications of Carprofen injection

Carprofen injection should not be used in cattle allergic to Carprofen. The drug can only be used by or on the order of a licensed veterinarian.

Animal safety: Laboratory studies and clinical field studies on unanaesthetized cattle have shown that carprofen is well tolerated in cattle after oral and subcutaneous administration.

Composition

Each ml contains:

Carprofen……………………….50mg       

Excipients up to…………………1ml

TARGET ANIMALS

Cattle.

Indications

The product is indicated as an adjunct to antimicrobial therapy to reduce clinical signs

in acute infectious respiratory disease and acute mastitis in cattle.

Dosage and administration

Subcutaneous or intravenous injection.

1.4 mg carprofen/ kg body weight (1 ml/35 kg) in combination with antibiotic therapy, as appropriate.

Contraindications

Do not use in animals suffering from cardiac, hepatic or renal impairment.

Do not use in animals suffering from gastro-intestinal ulceration or bleeding.

Withdrawal periods

Meat and offal:      21 days

Milk:                  Zero hours

STORAGE

Keep out of the sight and reach of children.

Do not store above 25 °C.

SHELF LIFE

3 years